Curcumin demonstrated to effectively prevent complications from diabetes mellitus including diabetic neuropathy
Type 2 diabetic mellitus (T2DM) has reached pandemic status and shows no signs of abatement.
Amazingly, the animal and cell research literature review concluded that curcumin could improve the type 2 diabetic state through 10 distinctly different mechanisms, such as:
As one kind of peripheral neuropathic pain, Diabetic neuropathy manifests typical chronic neuralgia symptoms, including hyperalgesia, allodynia, autotomy, and so on. The injured dorsal root ganglion (DRG) is considered as the first stage of the sensory pathway impairment, whose neurons display increased frequency of action potential generation and increased spontaneous activities. These are mainly due to the changed properties of voltage-gated sodium channels (VGSCs) and the increased sodium currents, especially TTX-R sodium currents. Curcumin, one of the most important phytochemicals from turmeric, has been demonstrated to effectively prevent and/or ameliorate diabetic mellitus and its complications including Diabetic neuropathy. The present study demonstrates that the TTX-R sodium currents of small-sized Dorsal root ganglion neurons isolated from Diabetic neuropathy are significantly increased. Such abnormality can be efficaciously eliminated by curcumin.